个人简介
王远强，博士/教授，重庆市免疫学会理事，重庆市生物信息学会理事
学习经历
1998.09-2002.06 重庆大学应用化学专业 理学学士
2002.09-2005.06 重庆大学药物化学专业 理学硕士
2009.09-2012.06 西南大学生物化学与分子生物专业 理学博士
工作经历
2013.06-2016.06 西南大学畜牧学流动站 博士后
2016.07-2016.10 波兰华沙社会科学与人文大学 交流学习
2017.08-2018.08 年在美国匹兹堡大学药学院 访问学者
2005.07- 重庆理工大学药学与生物工程学院
研究方向
(1)靶向药物筛选与评价；(2)多肽抗菌药物发现
科研成果
主持包括国家自然科学基金、中国博士后基金、重庆市自然科学基金等10余项科研项目资助，获重庆市技术发明三等奖1项，重庆市教学成果奖三等奖1项；授权国家发明专利4项；参编译著1部、教材1部；发表研究论文近90篇，其中SCI收录50余篇。
主持的部分科研项目
[1] 基于非天然氨基酸的高选择性小分子抗菌肽合理设计与构毒关系研究(31400667)，国家自然科学基金，2015.01-2017.12
[2] 基于BamA低突变区活性位点的抗耐药鲍曼不动杆菌非天然抗菌肽抑制剂筛选（CSTB2022NSCQ-MSX1327），重庆市科技局，2022.08-2025.07
[3] PD-1靶向多肽类蛋白-蛋白相互作用(PPI)调节剂的合理设计及效应研究(cstc2018jcyjAX0683)，重庆市科委，2018.07-2021.06，
[4] CTLA-4竞争性拟肽抑制剂设计与抗肿瘤作用机制研究(cstc2014jcyjA10044)，重庆市科委，2014.07-2017.06
[5] 小分子阳离子抗菌肽虚拟组合设计、筛选与效应研究(CSTC,2010BB5306)，重庆市科委，2010.10-2012.10
[6] PD-1靶向拟肽抑制剂设计与体外抗肿瘤效应研究(KJ1500902)，重庆市教委，2015.07-2017.07
[7] EBV天然CTL表位改造、筛选与免疫学效应研究，重庆市教委(KJ100801)，2010.01-2011.12
[8] 高选择性小分子抗菌肽的设计与筛选，中国博士后基金(2013M542240)，2013.06-2015.06
[9] 抗耐鲍曼不动杆菌抗菌环肽的结构优化与活性评价（cx2020012），重庆市人力资源和社会保障局，2021.1-2023.12
[10] 抗菌肽制备与抗耐药鲍曼不动杆菌活性评价，巴南区科技项目2019.1-2020.12，
[11] 抗菌肽抗耐药鲍曼不动杆菌作用机制研究(05161348z2k5)，家蚕基因组生物学国家重点实验室开放课题，2018.01-2019.12
[12] 小分子抗菌肽虚拟组合设计及其在家蚕中的应用，家蚕基因组生物学重点实验室课题(20120004)，2012.01-2014.12
[13] 活性多肽化合物筛选与制备，重庆龚州医药科技有限公司，2022.12-2023.12
[14] 复方阿胶浆成分库及靶点云计算平台的构建，东阿阿胶股份有限公司，2021.01-2022.01
[15] 高原心脏病新药蛋白间作用力计算与分析服务（yjx-yj-2021-5），陆军军医大学，2021.05-2022.04
[16] 反应机理计算服务，四川大学，2015.06-2015.12
代表性研究论文
[1] Zhao Linan, Fu Le, Li Guangping, Shen Yan, Hu, Yong, Chen Yan*, Wang Yuanqiang*. Target based structural optimization of substituted pyrazolopyrimidine analogues as inhibitor for IRAK4 by 3D‑QSAR and molecular simulation. Structural Chemistry. 2022.06, 33: 921-934.
[2] He Qingxiu, Zhao Linan, Li Guangping, Shen Yan*, Hu Yong, Wang Yuanqiang*. The antimicrobial cyclic peptide B2 combats multidrug resistant Acinetobacter Baumannii infection. New Journal of Chemistry. 2022.04.05, 46(14): 6577-6586.
[3] Tuo Yan, Li Guangping, Liu, Zhou, Yu Na, Li Yuepeng, Yang Li, Liu Haibin*, Wang Yuanqiang*. Discovery of novel antifungal resorcylate aminopyrazole Hsp90 inhibitors based on structural optimization by molecular simulations. New Journal of Chemistry. 2022.03.07, 46(10): 4890-4899.
[4] Nilupaier Tayier, Ningyi Qin, Linan Zhao, Yi Zeng, Yu Wang, Guang Hu*, Yuanqiang Wang*. Theoretical Exploring of a Molecular Mechanism for Melanin Inhibitory Activity of Calycosin in Zebrafish. Molecules. 2021.11, 26(22):6998.
[5] Mengjun Zhang#, Yuanqiang Wang#, Xiangqian Li, Gang Meng, Xiaoling Chen, Lina Wang, Zhihua Lin, Li Wang. A Single L/D-Substitution at Q4 of the mInsA2-10 Epitope Prevents Type 1 Diabetes in Humanized NOD Mice. Frontiers in Immunology. 2021.08.30, 12:713276.
[6] Guangping Li, Yuxuan Wang, Yan Shen, Haiqiong Guo, Qingxiu He, Yong Hu, Haibin Liu*, Zhihua Lin*, Yuanqiang Wang*. In silico design of antimicrobial oligopeptides based on 3D-QSAR modeling and bioassay evaluation. Medicinal Chemistry Research. 2021.11, 30(11): 2030-2041.
[7] Guangping Li, Haiqiong Guo, Linan Zhao, Huixian Feng, Huawei He, Yan Chen*, Yuanqiang Wang* and Zhihua Lin. Discovery of modulator for PD-1/PD-L1 interaction by molecular simulation and bioassay. New Journal of Chemistry, 2021.11.11, 45(39): 18497-18508. (SCI: WE4ZG)
[8] Guangping Li, Le Fu, Qingxiu He, Yong, Hu Xianlong Su, Haibin Liu*, Yuanqiang Wang*. Structural optimization for pyrimidine analogues inhibitors against MAP kinase interacting serine/threonine kinase 1(MNK1) based on molecular simulation. Journal of Molecular Structure. 2021.11.05, 1243: 130688.
[9] Xiaozhong Chen, Chen Dai, Yan Shen, Juan Wang, Yong Hu, Yuangiang Wang*, Zhi-Hua Lin*. 3D-QSAR, Docking, and Molecular Dynamics Simulations Studies on Quinazoline Derivatives as PAK4 Inhibitors. Letters in Drug Design & Discovery. 2021, 18(11): 1025-1038.
[10] Qingxiu He, Guangping Li, Haiqiong Guo, Yuxuan Wang, Han Chu, Yong Hu, Yan Shen, Zhihua Lin*, Yuanqiang Wang*. Discovery of Potential SARS-CoV-2 M Protease Inhibitors by Virtual Screening, Molecular Dynamics, and Binding Free Energy Analyses. Chinese Journal of Structural Chemistry, 2021.04.15, 40(4): 431-442. (SCI: RN2QN)
[11] Qingxiu He, Xin Chen, Xi Yang, Guangpin Li, Haiqiong Guo, Yuxuan Wang, Han Chu, Zhihua Lin*, Yuanqiang Wang*, Virtual Screening of Chinese Medicine Small Molecule Compounds Targeting SARS-CoV-2 3CL protease (3CL pro), Letter in Drug Design and Discovery. 2021.04.15, 18(4): 355-364.
[12] Xiaozhong Chen, Guangping Li, Yan Chen, Yong Hu, Juan Wang, Yuanqiang Wang*, Zhihua Lin*. Docking and 3D-QSAR Studies on the Imidazo[1,5-c]pyrimidine Derivative as EED Inhibitors[J]. Chinese Journal of Structural Chemistry. 2021, 40(06): 689-702.
[13] Han Chu, Qingxiu He, Juan Wang, Yong Hu, Yuanqiang Wang*, Zhihua Lin*. In silico design of novel benzohydroxamate-based compounds as inhibitors of histone deacetylase 6 based on 3D-QSAR, molecular docking, and molecular dynamics simulations. New Journal of Chemistry. 2020, 44: 21201-21210.
[14] Qingxiu He, Chu Han, Guangping Li, Haiqiong Guo, Yuxuan Wang, Yong Hu, Zhihua Lin*, Yuanqiang Wang*. In silico design novel (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine derivatives as inhibitors for glycogen synthase kinase 3 based on 3D-QSAR, molecular docking and molecular dynamics simulation, Computational Biology and Chemistry. 2020.10, 88:107328.
[15] Chu Han, He Qing-xiu, Wang Juan, Hu Yong, Wang Yuan-qiang*, Lin Zhi-hua*. In silico design novel dihydropyrimio [4, 5-d] pyrimidine derivatives as inhibitors for colony-stimulating factor-1 receptor based on 3D-QSAR, molecular docking and molecular dynamics simulation. Journal of Molecular Structure. 2020, 1220: 128617.
[16] Journigan V. Blair#,*, Feng Zhiwei#, Rahman Saifur#, Wang Yuanqiang#, Amin A. R. M. Ruhul, Heffner Colleen E., Bachtel Nicholas, Wang Siyi, Gonzalez-Rodriguez, Sara, Fernandez-Carvajal Asia, Fernandez-Ballester Gregorio, Hilton Jacob K., Van Horn Wade D., Ferrer-Montiel Antonio, Xie Xiang-Qun*, Rahman, Taufiq*. Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies. ACS Chemical Neuroscience. 2020, 11(3): 268-290
[17] Chu Han, He Qing-xiu, Wang Jun-wei, Deng Ya-ting, Wang Juan, Hu Yong, Wang Yuan-qiang*, Lin Zhi-hua*. 3D-QSAR, molecular docking, and molecular dynamics simulation of a novel thieno[3,4-d]pyrimidine inhibitor targeting human immunodeficiency virus type 1 reverse transcriptase. Journal Of Biomolecular Structure & Dynamics. 2020, 38(15):4567-4578.
[18] Qingxiu He, Han Chu, Yuxuan Wang, Haiqiong Guo, Yuanqiang Wang*, Siyi Wang, Zhiwei Feng*, Xiang-Qun Xie, Yong Hu, Haibin Liu & Zhihua Lin*. In silico design novel Vibsanin B derivatives as inhibitor for heat shock protein 90 based on 3D-QSAR, molecular docking and molecular dynamics simulation. Journal of Biomolecular Structure & Dynamics. 2020, 38(14): 4313-4324.
[19] Yuanqiang Wang*, Haiqiong Guo, Zhiwei Feng, Siyi Wang, Yuxuan Wang, Qingxiu He, Guangping Li, Weiwei Lin, Xiang-Qun Xie*, and Zhihua Lin*. PD-1-Targeted Discovery of Peptide Inhibitors by Virtual Screening, Molecular Dynamics Simulation, and Surface Plasmon Resonance. Molecules. 2019, 24(20): 3784.
[20] Guo Haiqiong, Wang Yuxuan, He Qingxiu, Zhang Yuping, Hu Yong, Wang Yuanqiang*, Lin Zhihua. In silico rational design and virtual screening of antixoidant tripeptides based on 3D-QSAR modeling. Journal of Molecular Structure. 2019, 1193: 223-230.
[21] Wang Yuan-Qiang, Lin Wei-Wei, Wu Nan, Wang Si-Yi, Chen Mao-Zi, Lin Zhi-Hua, Xie Xiang-Qun, Feng Zhi-Wei. Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis. Acta Pharmacologica Sinica. 2019, 40(9): 1138-1156.
[22] Wang Yuxuan, Guo Haiqiong, Tang Guanghui, He Qingxiu, Zhang Yuping, Hu, Yong, Wang Yuanqiang*, Lin Zhihua. A selectivity study of benzene sulfonamide derivatives on human carbonic anhydrase II/IX by 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation. Computational Biology and Chemistry. 2019. 80: 234-243
[23] Yuanqiang Wang#, Weiwei Lin#, Nan Wu#, Xibing He, Junmei Wang, Zhiwei Feng*, Xiang-Qun Xie*. An insight into paracetamol and its metabolites using molecular docking and molecular dynamics simulation. Journal of Molecular Modeling. 2018, 24(9):243.
[24] Guanhui Tang, Cheng Chen, Yuping Zhang, Ya Zhang, Yuanqinag Wang*, Zhihua Lin*. Theoretical modeling and systemic analysis of various active dipeptides and analogues with 3D-QSAR methods. Letters in Drug Design & Discovery. 2018, 15(9): 988-1001.
教学研究项目
[1] 创新药物发现能力为导向的《高等药物化学》教学探索与实践（yjs223129），重庆市教委，2023.01-2025.12
[2] 面向产出的教考分离与达成度分析平台建设（202002058022），教育部，2020.02-2023.02
[3] 产出导向的校企协同培养应用型制药人才体系实践(193181)，重庆市教委，2019.9-2021.8
[4] 应用型药学人才校企联合培养的长效机制研究与实践(2015-GX-031)，重庆市教育科学研究院，2015.12-2018.12
[5] 应用型药学人才“3+1”培养模式研究与实践(CQGJ13C442)，重庆市高等教育学会，2013.12-2015.12
联系方式
Email: wangyqnn@cqut.edu.cn, 7142084@qq.com
