王娟
发布时间:2017/09/25 11:01:41作者:责编:冉秋月阅读次数:

教师简介

王娟,重庆大学生物医学工程专业博士,讲师。主要从事疾病相关蛋白质靶标与配体识别及相互作用的分子模拟、靶向药物活性评价及机制研究。作为主要研究人员参与完成了包括国家自然科学基金、重庆市科委、重庆市教委等项目。近年来,已在《RSC Advances》、《molecular biosystems》、《protein and peptide letters》、《Progress in Biochemistry and Biophysic》等国内外重要学术期刊上发表研究论文20余篇,其中被SCI收录10余篇。

科研成果

(1)参研的科研项目

[1] 国家自然科学基金(重点)项目(11532004),骨关节系统软组织力学失稳损伤及修复的机制。

[2] 国家自然科学基金面上项目(81171508),HPV16型E7抗原CTL表位模拟肽抗HPV感染的实验研究。

[3] 国家自然科学基金面上项目(31170747),基于非蛋白氨基酸的小分子抗菌肽设计合成及生物效应研究。

[4] 重庆市科委基金项目(CSTC, 2010BB5304),基于结构信息的peptaibol抗菌肽全新设计。

[5] 重庆市教委基金项目(KJ110804),小分子抗菌肽设计、合成及活性评价。

(2)已发表的科研论文

[1] Juan Wang, Mao Shu, Yuanqiang Wang, Yuanliang Wang, Yong Hu and Zhihua Lin.Identification of potential CCR5 inhibitors through pharmacophore-based virtual screening, molecular dynamics simulation and binding free energy analysis. Mol. BioSyst., 2016, 12, 3396-3406.

[2] Juan Wang, Mao Shu, Xiaorong Wen, Yuanliang Wang, Yuanqiang Wang, Yong Hu and Zhihua Lin.Discovery of vascular endothelial growth factor receptor tyrosine kinase inhibitors by quantitative structure-activity relationships, molecular dynamics simulation and free energy calculation.RSC Adv., 2016, 6, 35402-35415.  

[3] Juan Wang, Mao Shu,Yong Lin,Yong Hu,Yingzi Han and Zhihua Lin.HPV16 E7 CTL Epitope Antigen Peptide Design and Activity Evaluation. PROG BIOCHEM BIOPHYS, 2015, 42, 1119-1127.

[4] Juan Wang, Xiaoyu Wang, Mao Shu, Yuanqiang Wang, Yong Lin, Li Wang, Xiaoming Cheng and Zhihua Lin.QSAR Study on MHC Class I A Alleles Based on the Novel Parameters of Amino Acids.PROTEIN PEPTIDE LETT, 2011, 18, 956-963.

[5] Rui Yu,Juan Wang, Xiaoli Zai, and Mao Shu. 3D-QSAR studies on 1, 2, 3, 4-tetradroquinoline derivatives as NMDAR antagonists. Computers and Applied Chemistry. 2016, 33, 80-84.

[6] Rui Yu,Juan Wang, Rui Wang, Yong Lin, Yong Hu, Yuanqiang Wang, Mao Shu, and Zhihua Lin. Combined Pharmacophore Modeling, 3D-QSAR, Homology Modeling and Docking Studies on CYP11B1 Inhibitors. Molecules, 2015, 20, 1014-1030.

[7] Yakuo LU,Juan Wang, Yong Hu Yong Lin and Zhihua Lin.Molecular modeling studies of vascular endothelial growth factor receptor tyrosine kinase inhibitorscombining molecular docking and3D-QSARmethods.Chinese J. Struct. Chem., 2013, 5, 679-694.

[8] Xiaoyu Wang,Juan Wang, Yong Lin, Yuan Ding, Yuanqiang Wang, Xiaoming Cheng and Zhihua Lin. QSAR Study on Angiotensin-Converting Enzyme Inhibitor Oligopeptides based on a novel set of sequence information descriptors. J Mol. Model, 2011, 17, 1599-1606.

[9] XiaoYu Wang,Juan Wang, Yong Hu, Yong Lin, Mao Shu, Li Wang, Xiaming Cheng and Zhihua Lin. Predicting the Activity of Peptides Based on Amino Acid Information.J Chin Chem Soc.2011, 58, 877-883.

[10]Yong Lin, Haixia Long,Juan Wang, Mao Shu, Yuanqiang Wang, Li Wang and Zhihua Lin. QSAR Study on Insect Neuropeptide Potencies Based on a Novel Set of Parameters of Amino Acids by Using OSC-PLS Method. Int J Pept Res Ther, 2011, 17, 201-208.

[11]Xiaoli Zai,Beina Zhang,Jing Li,JuanWang,Zhihua Lin,Mao Shu.Study of 1-H Pyrrolo[3, 2-c]pyridine MPS1 Inhibitors by Topomer CoMFA, Virtual screening and Molecular Dynamics Simulation.LAT AM J PHARM.

[12]Mao Shu, Rui Yu, Yunru Zhang,Juan Wang, Li Yang, Li Wang and Zhihua Lin.Predicting the Activity of Antimicrobial Peptides with Amino Acid Topological Information.MED CHEM, 2013, 9, 32-44.

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